منابع مشابه
Testicular Descent.
1Department of Urology, University General Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece; 2First Pediatric Surgery Clinic, Aghia Sophia Children’s Hospital, Athens, Greece; 3Department of Urology, Tottori University School of Medicine, Yonago, Japan; 4Laboratory of Molecular Urology and Genetics of Human Reproduction, Department of Urology, Ioannina Univers...
متن کاملGenetics and hormones in testicular descent.
Testicular descent is an essential part of normal male sexual development. Any anomaly that disrupts normal testicular descent will be clinically evident as cryptorchidism. Several factors, such as Hoxa-10, epidermal growth factor (EGF), calcitonin gene-related peptide (CGRP), and hormones, especially androgens and insulin-like factor 3 (INSL-3), have been suggested as being regulators of testi...
متن کاملThe regulation of testicular descent and the effects of cryptorchidism.
The first half of this review examines the boundary between endocrinology and embryonic development, with the aim of highlighting the way hormones and signaling systems regulate the complex morphological changes to enable the intra-abdominal fetal testes to reach the scrotum. The genitoinguinal ligament, or gubernaculum, first enlarges to hold the testis near the groin, and then it develops lim...
متن کاملAnatomical and functional aspects of testicular descent and cryptorchidism.
I. Normal Development A. Anatomical aspects 1. Sexual development 2. The gubernaculum 3. Cranial suspensory ligament 4. Abdominal pressure B. Hormonal control and functional aspects of testicular descent 1. Müllerian inhibiting substance 2. Androgen 3. The genitofemoral nerve (GFN) 4. Calcitonin gene-related peptide (CGRP) II. Cryptorchidism A. Etiology B. Frequency C. Are some UDT acquired? D....
متن کاملOrigin of INSL3-mediated testicular descent in therian mammals.
Testicular descent is a unique physiological adaptation found in therian mammals allowing optimal spermatogenesis below core body temperature. Recent studies show that INSL3, produced by Leydig cells, and its receptor LGR8 (RXFP2) are essential for mediating the transabdominal phase of testicular descent during early development. However, the origin and genetic basis for this physiological adap...
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ژورنال
عنوان ژورنال: HORMONES
سال: 2015
ISSN: 1109-3099
DOI: 10.14310/horm.2002.1634